9sie: Difference between revisions

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'''Unreleased structure'''


The entry 9sie is ON HOLD  until 2026-10-23
==Structure of the bacterial archaellum from L. aerophila==
<StructureSection load='9sie' size='340' side='right'caption='[[9sie]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9sie]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Litorilinea_aerophila Litorilinea aerophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SIE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sie OCA], [https://pdbe.org/9sie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sie RCSB], [https://www.ebi.ac.uk/pdbsum/9sie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sie ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A540VDN8_9CHLR A0A540VDN8_9CHLR]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Motility in Archaea is driven by the archaellum, a rotary ATP-driven machinery unrelated to the bacterial flagellum. To date, archaella have been described exclusively in archaea; however, recent work reported archaellum genes in bacterial strains of the SAR202 clade (Chloroflexota). Here, using MacSyFinder, we show that bona fide archaellum gene clusters are widespread in several members of the Chloroflexota. Analysis of archaellum-encoding loci and Alphafold3-predicted structures show similarity to the archaellum machinery. Using cryo electron microscopy single-particle analysis, we solved the structure of the bacterial archaellum from Litorilinea aerophila to 2.7 A. We also show the expression and assembly of this machinery in bacteria and its function in swimming motility. Finally, a phylogenomic analysis revealed two horizontal gene transfer events from euryarchaeal members to Chloroflexota. In summary, our study shows that a functional and assembled archaellum machinery can be exchanged between the two prokaryotic domains.


Authors: Sivabalasarma, S., Taib, N., Mollat, C.L., Joest, M., Steimle, S., Gribaldo, S., Albers, S.-V.
Structure of a functional archaellum in Bacteria of the Chloroflexota phylum.,Sivabalasarma S, Taib N, Mollat CL, Joest M, Steimle S, Gribaldo S, Albers SV Nat Microbiol. 2025 Oct;10(10):2412-2424. doi: 10.1038/s41564-025-02110-8. Epub , 2025 Sep 17. PMID:40962902<ref>PMID:40962902</ref>


Description: Structure of the bacterial archaellum from L. aerophila
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Gribaldo, S]]
<div class="pdbe-citations 9sie" style="background-color:#fffaf0;"></div>
[[Category: Mollat, C.L]]
== References ==
[[Category: Albers, S.-V]]
<references/>
[[Category: Steimle, S]]
__TOC__
[[Category: Joest, M]]
</StructureSection>
[[Category: Sivabalasarma, S]]
[[Category: Large Structures]]
[[Category: Taib, N]]
[[Category: Litorilinea aerophila]]
[[Category: Albers S-V]]
[[Category: Gribaldo S]]
[[Category: Joest M]]
[[Category: Mollat CL]]
[[Category: Sivabalasarma S]]
[[Category: Steimle S]]
[[Category: Taib N]]
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