9ue3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 9ue3 is ~~ON HOLD~~

==The structure of FIPV spike glycoprotein==

~~Authors~~: ~~Sun~~, J.Q., ~~Niu~~, S.

== Structural highlights ==

<table><tr><td colspan='2'>[[9ue3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_T6 Enterobacteria phage T6] and [https://en.wikipedia.org/wiki/Feline_infectious_peritonitis_virus_(strain_79-1146) Feline infectious peritonitis virus (strain 79-1146)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UE3 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9UE3 FirstGlance].

~~Description~~: The structure of ~~FIPV spike glycoprotein~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.78Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Sun, J.Q~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ue3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ue3 OCA], [https://pdbe.org/9ue3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ue3 RCSB], [https://www.ebi.ac.uk/pdbsum/9ue3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ue3 ProSAT]</td></tr>

[[Category: Niu, S]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/SPIKE_FIPV SPIKE_FIPV] S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04200][https://www.uniprot.org/uniprot/A0A346FJN8_BPT6 A0A346FJN8_BPT6]

__TOC__

</StructureSection>

[[Category: Enterobacteria phage T6]]

[[Category: Large Structures]]

[[Category: Niu S]]

[[Category: Sun JQ]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ue3 is ON HOLD
+==The structure of FIPV spike glycoprotein==
+<StructureSection load='9ue3' size='340' side='right'caption='[[9ue3]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
-Authors: Sun, J.Q., Niu, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ue3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_T6 Enterobacteria phage T6] and [https://en.wikipedia.org/wiki/Feline_infectious_peritonitis_virus_(strain_79-1146) Feline infectious peritonitis virus (strain 79-1146)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UE3 FirstGlance]. <br>
-Description: The structure of FIPV spike glycoprotein
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Sun, J.Q]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ue3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ue3 OCA], [https://pdbe.org/9ue3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ue3 RCSB], [https://www.ebi.ac.uk/pdbsum/9ue3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ue3 ProSAT]</span></td></tr>
-[[Category: Niu, S]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPIKE_FIPV SPIKE_FIPV] S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04200][https://www.uniprot.org/uniprot/A0A346FJN8_BPT6 A0A346FJN8_BPT6]
+__TOC__
+</StructureSection>
+[[Category: Enterobacteria phage T6]]
+[[Category: Large Structures]]
+[[Category: Niu S]]
+[[Category: Sun JQ]]