9v79: Difference between revisions

Latest revision as of 14:45, 10 February 2026

Structural basis of signal activation and transduction by chitin elicitor receptor kinase 1 in Oryza sativa

Structural highlights

9v79 is a 1 chain structure with sequence from Oryza sativa Japonica Group. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.12Å
Ligands:	ANP, MG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CERK1_ORYSJ Lysin motif (LysM) receptor kinase required as a cell surface receptor for chitin elicitor (chitooligosaccharides) signaling leading to innate immunity in response to biotic stresses. Involved in the resistance to pathogenic fungi, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP) (PubMed:21070404, PubMed:22891159, PubMed:24964058). Involved in the detection of microbial peptidoglycans (PGNs) and mediates PGN response (PubMed:24964058). Plays dual roles in PGN and chitin signaling during innate immunity. Acts as an adapter for LYP4 and LYP6 and mediates signal transduction from the extracellular to intracellular spaces. Participates in the activation of defense genes during response to PGN and chitin (PubMed:25335639). Phosphorylates the downstream partner RLCK185 in response to chitin elicitation (PubMed:23498959).^[1] ^[2] ^[3] ^[4] ^[5]

References

↑ Shimizu T, Nakano T, Takamizawa D, Desaki Y, Ishii-Minami N, Nishizawa Y, Minami E, Okada K, Yamane H, Kaku H, Shibuya N. Two LysM receptor molecules, CEBiP and OsCERK1, cooperatively regulate chitin elicitor signaling in rice. Plant J. 2010 Oct;64(2):204-14. doi: 10.1111/j.1365-313X.2010.04324.x. Epub 2010 , Sep 7. PMID:21070404 doi:https://dx.doi.org/10.1111/j.1365-313X.2010.04324.x
↑ Shinya T, Motoyama N, Ikeda A, Wada M, Kamiya K, Hayafune M, Kaku H, Shibuya N. Functional characterization of CEBiP and CERK1 homologs in arabidopsis and rice reveals the presence of different chitin receptor systems in plants. Plant Cell Physiol. 2012 Oct;53(10):1696-706. doi: 10.1093/pcp/pcs113. Epub 2012 , Aug 13. PMID:22891159 doi:https://dx.doi.org/10.1093/pcp/pcs113
↑ Yamaguchi K, Yamada K, Ishikawa K, Yoshimura S, Hayashi N, Uchihashi K, Ishihama N, Kishi-Kaboshi M, Takahashi A, Tsuge S, Ochiai H, Tada Y, Shimamoto K, Yoshioka H, Kawasaki T. A receptor-like cytoplasmic kinase targeted by a plant pathogen effector is directly phosphorylated by the chitin receptor and mediates rice immunity. Cell Host Microbe. 2013 Mar 13;13(3):347-57. doi: 10.1016/j.chom.2013.02.007. PMID:23498959 doi:https://dx.doi.org/10.1016/j.chom.2013.02.007
↑ Kouzai Y, Mochizuki S, Nakajima K, Desaki Y, Hayafune M, Miyazaki H, Yokotani N, Ozawa K, Minami E, Kaku H, Shibuya N, Nishizawa Y. Targeted gene disruption of OsCERK1 reveals its indispensable role in chitin perception and involvement in the peptidoglycan response and immunity in rice. Mol Plant Microbe Interact. 2014 Sep;27(9):975-82. doi:, 10.1094/MPMI-03-14-0068-R. PMID:24964058 doi:https://dx.doi.org/10.1094/MPMI-03-14-0068-R
↑ Ao Y, Li Z, Feng D, Xiong F, Liu J, Li JF, Wang M, Wang J, Liu B, Wang HB. OsCERK1 and OsRLCK176 play important roles in peptidoglycan and chitin signaling in rice innate immunity. Plant J. 2014 Dec;80(6):1072-84. doi: 10.1111/tpj.12710. PMID:25335639 doi:https://dx.doi.org/10.1111/tpj.12710

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OCA

[1] Shimizu T, Nakano T, Takamizawa D, Desaki Y, Ishii-Minami N, Nishizawa Y, Minami E, Okada K, Yamane H, Kaku H, Shibuya N. Two LysM receptor molecules, CEBiP and OsCERK1, cooperatively regulate chitin elicitor signaling in rice. Plant J. 2010 Oct;64(2):204-14. doi: 10.1111/j.1365-313X.2010.04324.x. Epub 2010 , Sep 7. PMID:21070404 doi:https://dx.doi.org/10.1111/j.1365-313X.2010.04324.x

[2] Shinya T, Motoyama N, Ikeda A, Wada M, Kamiya K, Hayafune M, Kaku H, Shibuya N. Functional characterization of CEBiP and CERK1 homologs in arabidopsis and rice reveals the presence of different chitin receptor systems in plants. Plant Cell Physiol. 2012 Oct;53(10):1696-706. doi: 10.1093/pcp/pcs113. Epub 2012 , Aug 13. PMID:22891159 doi:https://dx.doi.org/10.1093/pcp/pcs113

[3] Yamaguchi K, Yamada K, Ishikawa K, Yoshimura S, Hayashi N, Uchihashi K, Ishihama N, Kishi-Kaboshi M, Takahashi A, Tsuge S, Ochiai H, Tada Y, Shimamoto K, Yoshioka H, Kawasaki T. A receptor-like cytoplasmic kinase targeted by a plant pathogen effector is directly phosphorylated by the chitin receptor and mediates rice immunity. Cell Host Microbe. 2013 Mar 13;13(3):347-57. doi: 10.1016/j.chom.2013.02.007. PMID:23498959 doi:https://dx.doi.org/10.1016/j.chom.2013.02.007

[4] Kouzai Y, Mochizuki S, Nakajima K, Desaki Y, Hayafune M, Miyazaki H, Yokotani N, Ozawa K, Minami E, Kaku H, Shibuya N, Nishizawa Y. Targeted gene disruption of OsCERK1 reveals its indispensable role in chitin perception and involvement in the peptidoglycan response and immunity in rice. Mol Plant Microbe Interact. 2014 Sep;27(9):975-82. doi:, 10.1094/MPMI-03-14-0068-R. PMID:24964058 doi:https://dx.doi.org/10.1094/MPMI-03-14-0068-R

[5] Ao Y, Li Z, Feng D, Xiong F, Liu J, Li JF, Wang M, Wang J, Liu B, Wang HB. OsCERK1 and OsRLCK176 play important roles in peptidoglycan and chitin signaling in rice innate immunity. Plant J. 2014 Dec;80(6):1072-84. doi: 10.1111/tpj.12710. PMID:25335639 doi:https://dx.doi.org/10.1111/tpj.12710

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9v79 is ON HOLD  until Paper Publication
+==Structural basis of signal activation and transduction by chitin elicitor receptor kinase 1 in Oryza sativa==
+<StructureSection load='9v79' size='340' side='right'caption='[[9v79]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9v79]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza_sativa_Japonica_Group Oryza sativa Japonica Group]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V79 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v79 OCA], [https://pdbe.org/9v79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v79 RCSB], [https://www.ebi.ac.uk/pdbsum/9v79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v79 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CERK1_ORYSJ CERK1_ORYSJ] Lysin motif (LysM) receptor kinase required as a cell surface receptor for chitin elicitor (chitooligosaccharides) signaling leading to innate immunity in response to biotic stresses. Involved in the resistance to pathogenic fungi, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP) (PubMed:21070404, PubMed:22891159, PubMed:24964058). Involved in the detection of microbial peptidoglycans (PGNs) and mediates PGN response (PubMed:24964058). Plays dual roles in PGN and chitin signaling during innate immunity. Acts as an adapter for LYP4 and LYP6 and mediates signal transduction from the extracellular to intracellular spaces. Participates in the activation of defense genes during response to PGN and chitin (PubMed:25335639). Phosphorylates the downstream partner RLCK185 in response to chitin elicitation (PubMed:23498959).<ref>PMID:21070404</ref> <ref>PMID:22891159</ref> <ref>PMID:23498959</ref> <ref>PMID:24964058</ref> <ref>PMID:25335639</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Oryza sativa Japonica Group]]
+[[Category: Ming ZH]]
+[[Category: Su ZH]]

9v79: Difference between revisions

Latest revision as of 14:45, 10 February 2026

Structural basis of signal activation and transduction by chitin elicitor receptor kinase 1 in Oryza sativa

Structural highlights

Function

References

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