9z7p: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 9z7p is ON HOLD  until Paper Publication
==Stable open sheep connexin-46 in amphipol at low pH==
<StructureSection load='9z7p' size='340' side='right'caption='[[9z7p]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9z7p]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Z7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Z7P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9z7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9z7p OCA], [https://pdbe.org/9z7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9z7p RCSB], [https://www.ebi.ac.uk/pdbsum/9z7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9z7p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CXA3_SHEEP CXA3_SHEEP]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Gap junctions, formed by connexin proteins, establish direct electrical and metabolic coupling between cells, enabling coordinated tissue responses. These channels universally respond to intracellular pH changes, closing under acidic conditions to limit the spread of cytotoxic signals during cellular stress, such as ischemia. Using cryo-electron microscopy (cryo-EM), we uncover insights into the structural mechanism of pH-gating in native lens connexin-46/50 (Cx46/50) gap junctions. Mild acidification drives lipid infiltration into the channel pore, displacing the N-terminal (NT) domain and stabilizing pore closure. Lipid involvement is shown to be both essential and fully reversible. Structural transitions involve an ensemble of gated states formed through non-cooperative NT domain movement as well as minor populations of a distinct destabilized open-state. These findings provide molecular insights into pH-gating dynamics, illustrating how structural changes may regulate gap junction function under cellular stress and linking Cx46/50 dysregulation to age-related cataract formation.


Authors: Jarodsky, J.M., Myers, J.B., Reichow, S.L.
Reversible lipid-mediated pH-gating of connexin-46/50 by cryo-EM.,Jarodsky JM, Myers JB, Reichow SL Nat Commun. 2026 Jan 12. doi: 10.1038/s41467-026-68311-9. PMID:41526355<ref>PMID:41526355</ref>


Description: Stable open sheep connexin-46 in amphipol at low pH
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Reichow, S.L]]
<div class="pdbe-citations 9z7p" style="background-color:#fffaf0;"></div>
[[Category: Jarodsky, J.M]]
== References ==
[[Category: Myers, J.B]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ovis aries]]
[[Category: Jarodsky JM]]
[[Category: Myers JB]]
[[Category: Reichow SL]]
Retrieved from "https://proteopedia.org/9z7p"