9nx1: Difference between revisions

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'''Unreleased structure'''


The entry 9nx1 is ON HOLD  until Paper Publication
==Alpha7-nicotinic acetylcholine receptor bound to conotoxin ImII==
<StructureSection load='9nx1' size='340' side='right'caption='[[9nx1]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nx1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NX1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPJ:EPIBATIDINE'>EPJ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nx1 OCA], [https://pdbe.org/9nx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nx1 RCSB], [https://www.ebi.ac.uk/pdbsum/9nx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nx1 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The neuronal alpha7 nicotinic acetylcholine receptor (alpha7-nAChR) and muscle-type nicotinic acetylcholine receptor (mt-nAChR) are pivotal in synaptic signaling within the brain and the neuromuscular junction respectively. Additionally, they are both targets of a wide range of drugs and toxins. Here, we utilize cryo-EM to delineate structures of these nAChRs in complex with the conotoxins ImI and ImII from Conus imperialis. Despite nominal sequence differences, ImI and ImII exhibit discrete binding preferences and adopt drastically different conformational states upon binding. ImI engages the orthosteric sites of alpha7-nAChR, while ImII forms distinct pore-bound complexes with both alpha7-nAChR and mt-nAChR. Strikingly, ImII adopts a compact globular conformation that binds as a monomer to the alpha7-nAChR pore and as an oblate dimer to the mt-nAChR pore. These structures advance our understanding of nAChR-ligand interactions and the subtle sequence variations that result in dramatically altered functional outcomes in small peptide toxins.


Authors:  
Shape-shifting conotoxins reveal divergent pore-targeting mechanisms in nicotinic receptors.,Bhattacharjee B, Noviello CM, Rahman MM, Mayer JP, Gajewiak J, McIntosh JM, Hibbs RE, Stowell MHB Structure. 2025 Dec 29:S0969-2126(25)00484-8. doi: 10.1016/j.str.2025.12.003. PMID:41468893<ref>PMID:41468893</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 9nx1" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Conus imperialis]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bhattacharjee B]]
[[Category: Hibbs RE]]
[[Category: Noviello CM]]
[[Category: Stowell MHB]]
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