9nn4: Difference between revisions
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==BET BRD3-BD1 in complex with peptide 7.2== | |||
<StructureSection load='9nn4' size='340' side='right'caption='[[9nn4]], [[Resolution|resolution]] 1.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9nn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NN4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nn4 OCA], [https://pdbe.org/9nn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nn4 RCSB], [https://www.ebi.ac.uk/pdbsum/9nn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nn4 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The large size of macrocyclic peptides discovered by mRNA display can hinder therapeutic development. Using size-restricted RaPID libraries and analysis of 40 published datasets, we show that potent binders are more reliably identified from libraries with at least nine randomised residues, providing guidance for mRNA display screen design. | |||
The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides.,Jing X, Suh J, Maxwell J, Patel K, Norman A, Reid XJ, Deshpande C, Low JKK, Payne RJ, Passioura T, Mackay JP Chem Commun (Camb). 2026 Jan 30. doi: 10.1039/d5cc06167a. PMID:41614404<ref>PMID:41614404</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Jing | <div class="pdbe-citations 9nn4" style="background-color:#fffaf0;"></div> | ||
[[Category: Mackay | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Jing X]] | |||
[[Category: Mackay JP]] | |||
Latest revision as of 07:15, 11 February 2026
BET BRD3-BD1 in complex with peptide 7.2
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