9qrv: Difference between revisions

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'''Unreleased structure'''


The entry 9qrv is ON HOLD until Paper Publication
==Crystal Structure of an anti-VWF CK Domain Fab in Complex with the C-Terminal CK Domain of Cynomolgus Monkey von Willebrand Factor.==
 
<StructureSection load='9qrv' size='340' side='right'caption='[[9qrv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9qrv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QRV FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qrv OCA], [https://pdbe.org/9qrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qrv RCSB], [https://www.ebi.ac.uk/pdbsum/9qrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qrv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2K5X4G5_MACFA A0A2K5X4G5_MACFA] Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.[ARBA:ARBA00055715][PIRNR:PIRNR002495] Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.[ARBA:ARBA00059961]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Macaca fascicularis]]
[[Category: Synthetic construct]]
[[Category: Anthonsen A]]
[[Category: Bak-Thomsen T]]
[[Category: Carnbring Deemand A]]
[[Category: Gandhi P]]
[[Category: Gluver Norgaard H]]
[[Category: Hager M]]
[[Category: Kelpsas V]]
[[Category: Kempf-Amkaer L]]
[[Category: Naretto A]]
[[Category: Nielsen R]]
[[Category: Ostergaard H]]
[[Category: Rose N]]
[[Category: Sabljic I]]
[[Category: Walse B]]
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