9qo8: Difference between revisions
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==Inward-open structure of human GABA transporter 3 bound to selective inhibitor SR-THAP== | |||
<StructureSection load='9qo8' size='340' side='right'caption='[[9qo8]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9qo8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QO8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I87:(2~{S})-2-oxidanyl-2-[(2~{R})-1-[(~{E})-4,4,4-tris(4-methoxyphenyl)but-2-enyl]pyrrolidin-2-yl]ethanoic+acid'>A1I87</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qo8 OCA], [https://pdbe.org/9qo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qo8 RCSB], [https://www.ebi.ac.uk/pdbsum/9qo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qo8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/S6A11_HUMAN S6A11_HUMAN] Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity).[UniProtKB:P31650]<ref>PMID:7874447</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bavo F]] | |||
[[Category: Frolund B]] | |||
[[Category: Jensen MH]] | |||
[[Category: Mortensen JS]] | |||
[[Category: Pape T]] | |||
[[Category: Pedersen APS]] | |||
[[Category: Shahsavar A]] | |||
[[Category: Storm JP]] | |||
[[Category: Wellendorph P]] | |||
Latest revision as of 07:15, 18 February 2026
Inward-open structure of human GABA transporter 3 bound to selective inhibitor SR-THAP
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