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'''Unreleased structure'''


The entry 9odt is ON HOLD  until Paper Publication
==The structure of a Bacterial Cyanide Dihydratase from Bacillus safensis PER-URP-08==
<StructureSection load='9odt' size='340' side='right'caption='[[9odt]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9odt]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_safensis Bacillus safensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ODT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ODT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9odt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9odt OCA], [https://pdbe.org/9odt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9odt RCSB], [https://www.ebi.ac.uk/pdbsum/9odt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9odt ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cyanide is widely used in industries due to its affinity for metals, a property that also underlies its toxicity. Industries, therefore, must reduce cyanide concentration before the final disposal of wastewater. Physical, chemical, and biological methods have been developed for this; however, knowledge about the structure of enzymes involved in cyanide degradation remains limited. Structural characterization of these proteins could facilitate the development of enzymes with enhanced bioremediation potential. Here, we present the single-particle cryo-electron microscopy structures of a cyanide dihydratase from Bacillus safensis and a cyanide hydratase from Gloeocercospora sorghi at 2.2 A and 2.0 A resolution, respectively. We provide a comprehensive description and comparative analysis alongside all previously determined nitrilase structures. Importantly, our full-length structures reveal new features in the C-terminal as well as specific intermolecular interactions between protomer interfaces and within the helix lumen. Finally, our findings offer insights into the reaction mechanisms of these two enzymes.


Authors: Justo Arevalo, S., Valle-Riestra F, V., Balan, A., Chuck, C.S.
The single-particle cryo-EM structures of a bacterial cyanide dihydratase and a fungal cyanide hydratase.,Justo Arevalo S, Valle-Riestra Felice V, Barahona Acuna M, Ordinola Flores K, Quinones Aguilar M, Balan A, Farah CS Structure. 2026 Feb 17:S0969-2126(26)00011-0. doi: 10.1016/j.str.2026.01.009. PMID:41709456<ref>PMID:41709456</ref>


Description: The structure of a Bacterial Cyanide Dihydratase from Bacillus safensis PER-URP-08
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Valle-Riestra F, V]]
<div class="pdbe-citations 9odt" style="background-color:#fffaf0;"></div>
[[Category: Balan, A]]
== References ==
[[Category: Justo Arevalo, S]]
<references/>
[[Category: Chuck, C.S]]
__TOC__
</StructureSection>
[[Category: Bacillus safensis]]
[[Category: Large Structures]]
[[Category: Balan A]]
[[Category: Chuck CS]]
[[Category: Justo Arevalo S]]
[[Category: Valle-Riestra F V]]
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