9p53: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9p53 is ~~ON HOLD until Paper Publication~~

==ClpP1P2 complex from M. tuberculosis bound to Calprotamide A==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9p53]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P53 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9P53 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.77Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CHD:N-[(2R,4S)-2-ethyl-4-({(betaS)-N-[(2Z)-hex-2-enoyl]-beta-methyl-L-phenylalanyl}amino)-6-methyl-3-oxoheptanoyl]-L-alanine'>A1CHD</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9p53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p53 OCA], [https://pdbe.org/9p53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p53 RCSB], [https://www.ebi.ac.uk/pdbsum/9p53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p53 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CLPP2_MYCTU CLPP2_MYCTU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpX. Degrades anti-sigma-E factor RseA in the presence of ClpC1. Does not seem to act on anti-sigma-L factor RslA.[HAMAP-Rule:MF_00444]<ref>PMID:20025669</ref> <ref>PMID:23314154</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mycobacterium tuberculosis]]

[[Category: Brady SF]]

[[Category: Kan J]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9p53 is ON HOLD  until Paper Publication
+==ClpP1P2 complex from M. tuberculosis bound to Calprotamide A==
+<StructureSection load='9p53' size='340' side='right'caption='[[9p53]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9p53]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9P53 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CHD:N-[(2R,4S)-2-ethyl-4-({(betaS)-N-[(2Z)-hex-2-enoyl]-beta-methyl-L-phenylalanyl}amino)-6-methyl-3-oxoheptanoyl]-L-alanine'>A1CHD</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9p53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p53 OCA], [https://pdbe.org/9p53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p53 RCSB], [https://www.ebi.ac.uk/pdbsum/9p53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p53 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CLPP2_MYCTU CLPP2_MYCTU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpX. Degrades anti-sigma-E factor RseA in the presence of ClpC1. Does not seem to act on anti-sigma-L factor RslA.[HAMAP-Rule:MF_00444]<ref>PMID:20025669</ref> <ref>PMID:23314154</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis]]
+[[Category: Brady SF]]
+[[Category: Kan J]]