9zd0: Difference between revisions
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==C3 local refinement of Urea Transporter B (SLC14A1) bound to human stomatin oligomer== | |||
<StructureSection load='9zd0' size='340' side='right'caption='[[9zd0]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9zd0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZD0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr> | ||
[[Category: Clarke | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zd0 OCA], [https://pdbe.org/9zd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zd0 RCSB], [https://www.ebi.ac.uk/pdbsum/9zd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zd0 ProSAT]</span></td></tr> | ||
[[Category: Vallese | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/UT1_HUMAN UT1_HUMAN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Clarke OB]] | |||
[[Category: Vallese F]] | |||
Latest revision as of 07:44, 25 February 2026
C3 local refinement of Urea Transporter B (SLC14A1) bound to human stomatin oligomer
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