9zjs: Difference between revisions

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'''Unreleased structure'''


The entry 9zjs is ON HOLD until Paper Publication
==Human sterile alpha motif domain-containing protein 9 (SAMD9), asymmetric dimer "shell" shape==
 
<StructureSection load='9zjs' size='340' side='right'caption='[[9zjs]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9zjs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZJS FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zjs OCA], [https://pdbe.org/9zjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zjs RCSB], [https://www.ebi.ac.uk/pdbsum/9zjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zjs ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SAMD9_HUMAN SAMD9_HUMAN] MIRAGE syndrome;Familial normophosphatemic tumoral calcinosis. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Germline mutations in SAMD9 with a suppressive effect on the cell cycle are associated with somatic loss of the chromosome 7 harboring the mutant allele. This results in the deletion of several genes and predisposes to the development of myelodysplastic syndrome and acute myelogenous leukemia.<ref>PMID:30046003</ref>
== Function ==
[https://www.uniprot.org/uniprot/SAMD9_HUMAN SAMD9_HUMAN] Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules (PubMed:25428864, PubMed:28157624). May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion.<ref>PMID:16960814</ref> <ref>PMID:18094730</ref> <ref>PMID:21160498</ref> <ref>PMID:24029230</ref> <ref>PMID:25428864</ref> <ref>PMID:28157624</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dai X]]
[[Category: Mou Z]]
[[Category: Xiang Y]]
[[Category: Zhang F]]
Retrieved from "https://proteopedia.org/9zjs"