6shk: Difference between revisions
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==High resolution structure of the antimicrobial peptide Dermcidin from human== | |||
<StructureSection load='6shk' size='340' side='right'caption='[[6shk]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6shk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SHK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.992Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Zeth | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6shk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6shk OCA], [https://pdbe.org/6shk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6shk RCSB], [https://www.ebi.ac.uk/pdbsum/6shk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6shk ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DCD_HUMAN DCD_HUMAN] DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.<ref>PMID:17448443</ref> Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.<ref>PMID:17448443</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Zeth K]] | |||
Latest revision as of 08:18, 4 March 2026
High resolution structure of the antimicrobial peptide Dermcidin from human
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