7zjv: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/USPL1_HUMAN USPL1_HUMAN] SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).<ref>PMID:22878415</ref> <ref>PMID:24413172</ref> | [https://www.uniprot.org/uniprot/USPL1_HUMAN USPL1_HUMAN] SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).<ref>PMID:22878415</ref> <ref>PMID:24413172</ref> | ||
==See Also== | |||
*[[SUMO 3D Structures|SUMO 3D Structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Latest revision as of 08:53, 4 March 2026
Structure of human USPL1 in covalent complex with DeltaN-SUMO2/3-PA probe
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