1xm9: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1xm9.gif|left|200px]] | [[Image:1xm9.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1xm9", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
--> | |||
{{STRUCTURE_1xm9| PDB=1xm9 | SCENE= }} | |||
| | |||
}} | |||
'''Structure of the armadillo repeat domain of plakophilin 1''' | '''Structure of the armadillo repeat domain of plakophilin 1''' | ||
| Line 30: | Line 27: | ||
[[Category: Choi, H J.]] | [[Category: Choi, H J.]] | ||
[[Category: Weis, W I.]] | [[Category: Weis, W I.]] | ||
[[Category: | [[Category: Armadillo repeat]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:12:49 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 12:12, 3 May 2008
Structure of the armadillo repeat domain of plakophilin 1
Overview
The p120ctn subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins.
Disease
Known disease associated with this structure: Ectodermal dysplasia/skin fragility syndrome OMIM:[601975]
About this Structure
1XM9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the armadillo repeat domain of plakophilin 1., Choi HJ, Weis WI, J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:15663951 Page seeded by OCA on Sat May 3 15:12:49 2008
