9uwy: Difference between revisions

Latest revision as of 09:16, 11 March 2026

Cryo-EM structure of the human P2X2 receptor in the ATP-bound desensitised state

Structural highlights

9uwy is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.48Å
Ligands:	ATP, NAG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

P2RX2_HUMAN Rare autosomal dominant non-syndromic sensorineural deafness type DFNA. The disease is caused by variants affecting the gene represented in this entry.

Function

P2RX2_HUMAN ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).[UniProtKB:Q8K3P1]^[1] ^[2] ^[3]

References

↑ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF. Molecular and functional characterization of human P2X(2) receptors. Mol Pharmacol. 1999 Dec;56(6):1171-81. PMID:10570044 doi:10.1124/mol.56.6.1171
↑ Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2228-33. PMID:23345450 doi:10.1073/pnas.1222285110
↑ George B, Swartz KJ, Li M. Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22862-22871. PMID:31636190 doi:10.1073/pnas.1912156116

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF. Molecular and functional characterization of human P2X(2) receptors. Mol Pharmacol. 1999 Dec;56(6):1171-81. PMID:10570044 doi:10.1124/mol.56.6.1171

[2] Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2228-33. PMID:23345450 doi:10.1073/pnas.1222285110

[3] George B, Swartz KJ, Li M. Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22862-22871. PMID:31636190 doi:10.1073/pnas.1912156116

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[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9uwy is ON HOLD  until 2027-05-13
+==Cryo-EM structure of the human P2X2 receptor in the ATP-bound desensitised state==
+<StructureSection load='9uwy' size='340' side='right'caption='[[9uwy]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
-Authors: Zhang, J., Cheng, X.Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9uwy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UWY FirstGlance]. <br>
-Description: Cryo-EM structure of the human P2X2 receptor in the ATP-bound desensitised state
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Zhang, J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uwy OCA], [https://pdbe.org/9uwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uwy RCSB], [https://www.ebi.ac.uk/pdbsum/9uwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uwy ProSAT]</span></td></tr>
-[[Category: Cheng, X.Y]]
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/P2RX2_HUMAN P2RX2_HUMAN] Rare autosomal dominant non-syndromic sensorineural deafness type DFNA. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/P2RX2_HUMAN P2RX2_HUMAN] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).[UniProtKB:Q8K3P1]<ref>PMID:10570044</ref> <ref>PMID:23345450</ref> <ref>PMID:31636190</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cheng XY]]
+[[Category: Zhang J]]

9uwy: Difference between revisions

Latest revision as of 09:16, 11 March 2026

Cryo-EM structure of the human P2X2 receptor in the ATP-bound desensitised state

Structural highlights

Disease

Function

References

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