9l60: Difference between revisions

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'''Unreleased structure'''


The entry 9l60 is ON HOLD  until Paper Publication
==Gi-bound kappa opioid receptor in complex with dynorphin and positive allosteric modulator MPAM-15==
 
<StructureSection load='9l60' size='340' side='right'caption='[[9l60]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
Authors: Zhuang, Y., Wang, Y., Xu, Y., Luo, P., Xu, H.E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9l60]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L60 FirstGlance]. <br>
Description: Gi-bound kappa opioid receptor in complex with dynorphin and positive allosteric modulator MPAM-15
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D6C:9-[5-(3-chlorophenyl)furan-2-yl]-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2~{H}-xanthene-1,8-dione'>A1D6C</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
[[Category: Wang, Y]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l60 OCA], [https://pdbe.org/9l60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l60 RCSB], [https://www.ebi.ac.uk/pdbsum/9l60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l60 ProSAT]</span></td></tr>
[[Category: Zhuang, Y]]
</table>
[[Category: Xu, Y]]
== Function ==
[[Category: Xu, H.E]]
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
[[Category: Luo, P]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Luo P]]
[[Category: Wang Y]]
[[Category: Xu HE]]
[[Category: Xu Y]]
[[Category: Zhuang Y]]
Retrieved from "https://proteopedia.org/9l60"