9m9w: Difference between revisions

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'''Unreleased structure'''


The entry 9m9w is ON HOLD  until Paper Publication
==The structure of THIK1-R92S==
 
<StructureSection load='9m9w' size='340' side='right'caption='[[9m9w]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9m9w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M9W FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.87&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m9w OCA], [https://pdbe.org/9m9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m9w RCSB], [https://www.ebi.ac.uk/pdbsum/9m9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m9w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCNKD_HUMAN KCNKD_HUMAN] K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:24163367, PubMed:25148687, PubMed:30472253, PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:25148687). Contributes most of K(+) currents at the plasma membrane of resting microglia. Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:38409076). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity) (PubMed:38409076).[UniProtKB:Q8R1P5]<ref>PMID:24163367</ref> <ref>PMID:25148687</ref> <ref>PMID:30472253</ref> <ref>PMID:38409076</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dai Z]]
[[Category: Yin YX]]
Retrieved from "https://proteopedia.org/9m9w"