9ogh: Difference between revisions

Latest revision as of 07:37, 19 March 2026

Human P2X2 apo structure in lipid nanodiscs

Structural highlights

9ogh is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.7Å
Ligands:	NA, NAG, POV
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

P2RX2_HUMAN Rare autosomal dominant non-syndromic sensorineural deafness type DFNA. The disease is caused by variants affecting the gene represented in this entry.

Function

P2RX2_HUMAN ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).[UniProtKB:Q8K3P1]^[1] ^[2] ^[3]

References

↑ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF. Molecular and functional characterization of human P2X(2) receptors. Mol Pharmacol. 1999 Dec;56(6):1171-81. PMID:10570044 doi:10.1124/mol.56.6.1171
↑ Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2228-33. PMID:23345450 doi:10.1073/pnas.1222285110
↑ George B, Swartz KJ, Li M. Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22862-22871. PMID:31636190 doi:10.1073/pnas.1912156116

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF. Molecular and functional characterization of human P2X(2) receptors. Mol Pharmacol. 1999 Dec;56(6):1171-81. PMID:10570044 doi:10.1124/mol.56.6.1171

[2] Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2228-33. PMID:23345450 doi:10.1073/pnas.1222285110

[3] George B, Swartz KJ, Li M. Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22862-22871. PMID:31636190 doi:10.1073/pnas.1912156116

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[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ogh is ON HOLD  until Paper Publication
+==Human P2X2 apo structure in lipid nanodiscs==
+<StructureSection load='9ogh' size='340' side='right'caption='[[9ogh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ogh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OGH FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ogh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ogh OCA], [https://pdbe.org/9ogh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ogh RCSB], [https://www.ebi.ac.uk/pdbsum/9ogh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ogh ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/P2RX2_HUMAN P2RX2_HUMAN] Rare autosomal dominant non-syndromic sensorineural deafness type DFNA. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/P2RX2_HUMAN P2RX2_HUMAN] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).[UniProtKB:Q8K3P1]<ref>PMID:10570044</ref> <ref>PMID:23345450</ref> <ref>PMID:31636190</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Dhingra S]]
+[[Category: Swartz KJ]]

9ogh: Difference between revisions

Latest revision as of 07:37, 19 March 2026

Human P2X2 apo structure in lipid nanodiscs

Structural highlights

Disease

Function

References

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