9m1y: Difference between revisions

Latest revision as of 08:57, 19 March 2026

NMR Structure of Mouse Keratin 17 Tail Domain (G390 - R433) in solution

Structural highlights

9m1y is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR, models
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

K1C17_MOUSE Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (PubMed:14714564, PubMed:16702408). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:16702408). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.^[1] ^[2] ^[3] ^[4] ^[5]

References

↑ Fan W, Yoon K. In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide-directed gene targeting. Exp Dermatol. 2003 Dec;12(6):832-42. PMID:14714564 doi:10.1111/j.0906-6705.2003.00099.x
↑ Tong X, Coulombe PA. Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev. 2006 May 15;20(10):1353-64. PMID:16702408 doi:10.1101/gad.1387406
↑ Kim S, Wong P, Coulombe PA. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature. 2006 May 18;441(7091):362-5. PMID:16710422 doi:10.1038/nature04659
↑ Depianto D, Kerns ML, Dlugosz AA, Coulombe PA. Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet. 2010 Oct;42(10):910-4. PMID:20871598 doi:10.1038/ng.665
↑ McGowan KM, Coulombe PA. Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol. 1998 Oct 19;143(2):469-86. PMID:9786956 doi:10.1083/jcb.143.2.469

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Fan W, Yoon K. In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide-directed gene targeting. Exp Dermatol. 2003 Dec;12(6):832-42. PMID:14714564 doi:10.1111/j.0906-6705.2003.00099.x

[2] Tong X, Coulombe PA. Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev. 2006 May 15;20(10):1353-64. PMID:16702408 doi:10.1101/gad.1387406

[3] Kim S, Wong P, Coulombe PA. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature. 2006 May 18;441(7091):362-5. PMID:16710422 doi:10.1038/nature04659

[4] Depianto D, Kerns ML, Dlugosz AA, Coulombe PA. Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet. 2010 Oct;42(10):910-4. PMID:20871598 doi:10.1038/ng.665

[5] McGowan KM, Coulombe PA. Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol. 1998 Oct 19;143(2):469-86. PMID:9786956 doi:10.1083/jcb.143.2.469

[1]

[2]

[3]

[4]

[5]

@@ Line 4: / Line 4: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[9m1y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M1Y FirstGlance]. <br>
-</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 17 models</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR,  models</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m1y OCA], [https://pdbe.org/9m1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m1y RCSB], [https://www.ebi.ac.uk/pdbsum/9m1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m1y ProSAT]</span></td></tr>
 </table>

9m1y: Difference between revisions

Latest revision as of 08:57, 19 March 2026

NMR Structure of Mouse Keratin 17 Tail Domain (G390 - R433) in solution

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools