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'''Unreleased structure'''


The entry 10fe is ON HOLD
==OX1-Germline in complex with GluN1-GluN2B, full refinement==
 
<StructureSection load='10fe' size='340' side='right'caption='[[10fe]], [[Resolution|resolution]] 4.55&Aring;' scene=''>
Authors: Kleeman, S.O., Furukawa, H.F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[10fe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10FE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10FE FirstGlance]. <br>
Description: OX1-Germline in complex with GluN1-GluN2B, full refinement
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.55&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10fe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10fe OCA], [https://pdbe.org/10fe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10fe RCSB], [https://www.ebi.ac.uk/pdbsum/10fe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10fe ProSAT]</span></td></tr>
[[Category: Kleeman, S.O]]
</table>
[[Category: Furukawa, H.F]]
== Disease ==
[https://www.uniprot.org/uniprot/NMDZ1_HUMAN NMDZ1_HUMAN] Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:[https://omim.org/entry/614254 614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21376300</ref>
== Function ==
[https://www.uniprot.org/uniprot/NMDZ1_HUMAN NMDZ1_HUMAN] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Furukawa HF]]
[[Category: Kleeman SO]]
Retrieved from "https://proteopedia.org/10fe"