10fl: Difference between revisions
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==SK5G-Germline== | |||
<StructureSection load='10fl' size='340' side='right'caption='[[10fl]], [[Resolution|resolution]] 3.81Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[10fl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10FL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10FL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.81Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10fl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10fl OCA], [https://pdbe.org/10fl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10fl RCSB], [https://www.ebi.ac.uk/pdbsum/10fl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10fl ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Furukawa | == Disease == | ||
[https://www.uniprot.org/uniprot/NMDZ1_HUMAN NMDZ1_HUMAN] Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:[https://omim.org/entry/614254 614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21376300</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NMDZ1_HUMAN NMDZ1_HUMAN] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Furukawa HF]] | |||
[[Category: Kleeman SO]] | |||
