9num: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9num is ~~ON HOLD until Paper Publication~~

==SsoPfMCM:DNA class 3 from merged particles==

~~Authors~~: ~~Enemark~~, E.J., ~~Rasouli~~, S., ~~Myasnikov~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[9num]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638], [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NUM OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9NUM FirstGlance].

~~Description~~: ~~SsoPfMCM~~:~~DNA class 3 from merged particles~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.67Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Rasouli, S~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9num FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9num OCA], [https://pdbe.org/9num PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9num RCSB], [https://www.ebi.ac.uk/pdbsum/9num PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9num ProSAT]</td></tr>

[[Category: Myasnikov, A]]

</table>

[[Category: ~~Enemark, E.J~~]]

== Function ==

[https://www.uniprot.org/uniprot/MCM_SACS2 MCM_SACS2] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Pyrococcus furiosus DSM 3638]]

[[Category: Saccharolobus solfataricus P2]]

[[Category: Synthetic construct]]

[[Category: Enemark EJ]]

[[Category: Myasnikov A]]

[[Category: Rasouli S]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9num is ON HOLD  until Paper Publication
+==SsoPfMCM:DNA class 3 from merged particles==
+<StructureSection load='9num' size='340' side='right'caption='[[9num]], [[Resolution|resolution]] 3.67&Aring;' scene=''>
-Authors: Enemark, E.J., Rasouli, S., Myasnikov, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9num]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638], [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NUM FirstGlance]. <br>
-Description: SsoPfMCM:DNA class 3 from merged particles
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.67&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Rasouli, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9num FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9num OCA], [https://pdbe.org/9num PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9num RCSB], [https://www.ebi.ac.uk/pdbsum/9num PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9num ProSAT]</span></td></tr>
-[[Category: Myasnikov, A]]
+</table>
-[[Category: Enemark, E.J]]
+== Function ==
+[https://www.uniprot.org/uniprot/MCM_SACS2 MCM_SACS2] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Pyrococcus furiosus DSM 3638]]
+[[Category: Saccharolobus solfataricus P2]]
+[[Category: Synthetic construct]]
+[[Category: Enemark EJ]]
+[[Category: Myasnikov A]]
+[[Category: Rasouli S]]