Beta-lactamase 3D structures: Difference between revisions

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*β-lactamase class A

**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]], [[5npo]], [[7u6q]], [[8gii]] - EcBlac A Tem-1- ''Escherichia coli''

**[[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[3dtm]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]], [[6ayk]], [[6apa]], [[8ddz]], [[8gij]], [[8rqu]] - EcBlac A Tem-1 (mutant)   

**[[8qnn]] – Blac A – ''Nocardia cyriacigeorgica''<br />

**[[8iwv]] – YeBlac A – ''Yersinia enterocolitica''<br />

*β-lactamase class A binary complex

**[[1axb]], [[5ksc]] - EcBlac A (mutant) + transition state analog<br />

**[[5ujo]] - EcBlac A (mutant) + organometallics<br />

**[[6w33]] – BcBlac A (mutant) + inhibitor <br />

**[[9bzr]] - BbBlac A + drug<br />

*β-lactamase class A binary complex with antibiotics

**[[7qlp]], [[7qnk]] – EcBlac Tem-171 + antibiotic<br />

**[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br />

**[[9bzq]] - BbBlac A + antibiotic<br />

**[[8eo6]] - meBlac A + antibiotic<br />

*Extended-spectrum β-lactamase class A

**[[3ni9]] - PaESBL A Ges-2<br />

**[[4gnu]], [[4h8r]] - PaESBL A Ges-5<br />

**[[5gs8]] – SmESBL Tla-3 <br />

**[[6bn3]] – SeESBL Ctx-M-151 – ''Salmonela enterica''<br />

*Extended-spectrum β-lactamase class A binary complex

**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br />

**[[3nia]] - PaESBL A GES-2 + inhibitor<br />

**[[7bds]] – KpESBL Ctx-M-15 + drug <br />

**[[7bdr]], [[7qq5]] – KpESBL Ctx-M-15 (mutant) + drug <br />

*Extended-spectrum β-lactamase class A binary complex with antibiotics

**[[4qu3]] - PaESBL A Ges-2 + antibiotic<br />

**[[5eph]], [[5eua]] – PaESBL Bel-1 + antibiotic<br />

**[[5gwa]], [[7o0o]] – SmESBL Tla-3 + antibiotic<br />

**[[8isp]], [[8isq]], [[8isr]] - StmESBL (mutant) + antibiotic<br />

*beta-lactamase class A complex with β-lactamase inhibitor protein (Blip)

**[[1jtg]], [[2b5r]], [[3c7u]], [[3c7v]] – EcBlac A (mutant) + Protein Blip

**[[1jtd]], [[3gmw]] - EcBlac A + Protein Blip

**[[3e2k]], [[3e2l]] - KpBlac A Kpc-2 (mutant) + Protein Blip

**[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis''

*beta-lactamase class B (Zn containing) or metallo-beta-lactamase or NDM

**[[1bc2]], [[1bmc]], [[1bvt]], [[1mqo]], [[2bc2]], [[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[3bc2]], [[4c09]], [[4nq4]], [[5fqa]], [[6dja]] – BcBlac B  

**[[2m5c]] - BcBlac B – NMR<br />

**[[6v72]], [[6v73]] – ElBlac – ''Erythrobacter litoralis''<br />

**[[6jv4]] - VaBlac Vmb-1 – ''Vibrio alginolyticus''<br />

*beta-lactamase class B binary complex with antibiotic

**[[5n5i]] - PaBlac B Vim-1 + antibiotic<br />

**[[4s2o]], [[5mox]], [[5moz]], [[9ixr]] - PaBlac Oxa-10 + antibiotic<br />

**[[6ol8]] – EcBlac B Ndm-12 + antibiotic<br />

**[[6lf4]] - VaBlac Vmb-1 + antibiotic <br />

*beta-lactamase class B binary complex

**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor

**[[5w90]] – FgBlac + captopril  

**[[6v61]] – HbBlac (mutant) + inhibitor<br />

**[[8a76]], [[8b1w]], [[8b1z]], [[8b20]] – PaBlac B Ndm-1+ inhibitor<br />

*beta-lactamase class C

**[[5f1g]], [[5ggw]], [[6g9t]], [[6xg1]] – EcBlac C<br />

**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant)  

**[[8fqt]] – AbBlac C Adc-219<br />

**[[6fm6]] - Blac C Tru-1 – ''Aeromonas enteropelogenes''<br />

*beta-lactamase class C binary complex

**[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]], [[6xfs]] - EcBlac C + inhibitor

**[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor

**[[6fm7]]  - Blac C Tru-1 + inhibitor <br />

**[[5k1f]]  - EaBlac C + inhibitor <br />

*beta-lactamase class D

**[[1k55]], [[1k57]], [[1k4e]], [[1ewz]], [[1fof]], [[1ddk]], [[1e3u]], [[1e4d]], [[1h8z]], [[2rl3]] – PaBlac D  

**[[2hp5]], [[2hp6]], [[2hp9]], [[2hpb]], [[2wgw]], [[2wki]] - PaBlac D (mutant)  

**[[6w5o]] – BaBlac D (mutant) <br />

**[[7k3m]] – CpBlac D <br />

*beta-lactamase class D binary complex

**[[1k6s]] - PaBlac D + phenylboronic acid

**[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor

**[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br />

**[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]], [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]], [[6uvk]], [[6v1o]], [[7ass]], [[7aux]], [[7aw5]], [[7jhq]], [[7k5v]], [[7l8o]], [[7r6z]], [[8faj]], [[8sqf]], [[8sqg]] - KpBlac D Oxa-48 + inhibitor<br />

*beta-lactamase class D binary complex with antibiotics

**[[1k6r]], [[1k54]], [[7l5t]] - PaBlac D + antibiotic

**[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic

**[[6xj3]], [[8qnz]] - KpBlac D + antibiotic<br />

**[[8ep6]] – CpBlac + antibiotic – ''Chitinophaga pinensis''<br />

*AmpC beta-lactamase

**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]], [[6t3d]], [[7cin]] – EcBlac

**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant)

**[[5e2h]] – Blac – ''Mycobacterium smegmatis''<br />

**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br />

*AmpC beta-lactamase binary complex

**[[1fcn]] – EcBlac (mutant) + substrate

**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]], [[4jxg]], [[6t35]], [[6t5y]], [[6tbw]], [[9c6p]]- EcBlac + antibiotic

**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor

**[[6s1s]], [[8sdr]], [[8sdt]] - PaBlac + boronic acid inhibitor<br />

*Carbapenemase

**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''

**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)

**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />

**[[8ehu]] – ChBlac A – ''Chromobacterterium haemolyticum''<br />

* Carbapenemase binary complexes

**[[6p97]], [[6p98]], [[6p99]], [[6p9c]], [[6pk0]] - KpBlac Oxa-48 + antibiotic<br />

**[[67dml]] - KpBlac Oxa-48 + inhibitor<br />

Non-classified beta-lactamase

**[[1bsg]] – Blac – ''Streptomyces albus''

**[[6wgr]] -  SaBlac <br />

  Non-classified beta-lactamase binary complex

**[[1ghm]], [[1ghp]], [[1pio]] - SaBlac (mutant) + antibiotic

**[[1blc]], [[1blh]] – SaBlac + inhibitor

**[[7doo]] – BmBlac + antibiotic <br />

**[[7ddm]] – BmBlac + peptide <br />

*Serine beta-lactamase (ClbP)

**[[7mde]], [[7mdf]] – EcClbP  (mutant)<br />

**[[7ul6]] – EcClbP – Cryo EM <br />