Elongation factor 3D structures: Difference between revisions

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*EF-Tu

**[[1ls2]] – yEF + Phe-tRNA – yeast – Cryo EM<BR />

**[[1efm]], [[1efc]], [[1dg1]], [[2fx3]], [[1etu]], [[5mi3]] – EcEF – ''Escherichia coli''<BR />

**[[5tbf]] – EF domain 2-3– ''Vibrio cholerae"

**[[5w76]], [[6htw]], [[6i8r]], [[7bbn]] – EF – synthetic<br />

*''EF-Tu complex with antibiotics''

**[[1ob2]] - yEF + Phe-tRNA + antibiotic<BR />

**[[4v8q]] - TtEF + antibiotic in 30S ribosome<BR />

**[[1d8t]], [[2hcj]], [[2hdn]], [[3u6b]], [[3u6k]], [[4g5g]], [[5jbq]], [[8fr3]] – EcEF + antibiotic<br />

**[[7st7]] – EcEF + antibiotic in 70S ribosome – Cryo EM<BR />

*''EF-Tu complex with nucleotide''

**[[1d2e]] – bEF + GDP – bovine<BR />

**[[6eze]] – EcEF + GDP derivative<BR />

**[[6gfu]] – EF + GDP – synthetic<br />

**[[7vok]] – MtEF + GDP – ''Mycobacterium tuberculosis''<br />

*''EF-Tu complex with protein''

**[[3vmf]] – ApEF + translation termination factor<br />

**[[3wy9]] – PhEF + L12 <br />

**[[5v7y]] – EF + prolyl hydroxylase – ''Bacillus anthracis''<br />

**[[8xi2]] – EF in C* complex – ''Chlamydomonas reinhardtii'' – Cryo EM <br />

*''EF-Tu with EF-Ts''

**[[1xb2]] – bEF + EF-Ts - bovine<BR />

**[[1f60]]  – yEF + EF-Ts C terminal<BR />

**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />

**[[7vmx]] – MtEF + MtEF-Ts <br />

*''EF-Tu in the ribosome''

**[[7a5g]], [[7o9k]] – hEF in 80S mitoribosome + GMPPCP – Cryo EM<BR />

**[[3eq3]], [[3eq4]], [[5afi]] – EcEF in 80S ribosome – Cryo EM<BR />

**[[4v5g]], [[4v5l]], [[4v5p]], [[4v5q]], [[4v5r]], [[4v5s]] - TtEF in 70S ribosome

**[[8v9l]] – EF in 70S ribosome – ''Mycobacterium smegmatis'' - Cryo EM<BR />

*EF-SII

**[[1tfi]] – hEF – human – NMR<BR />

**[[3ndq]] - hEF domain II<BR />

**[[2m1h]] – TbEF PWWP domain – ''Trypanosoma brucei'' – NMR<br />

**[[7xgw]] – TbEF LN domain <br />

*EF-ELL2

**[[2e5n]] – hEF N2 domain - NMR<BR />

**[[5jw9]] – hEF + AFF4 peptide<br />

*EF-G

**[[1efg]], [[1elo]], [[1ktv]], [[1wdt]], [[2dy1]] – TtEF<BR />

**[[4m1k]], [[4myt]], [[4myu]] – TtEF (mutant)<br />

**[[3zz0]], [[3zzt]], [[3zzu]] – SaEF (mutant) <BR />

**[[2mzw]] – SaEF domains III-V + FAR1<BR />

*''EF-G in the ribosome''

**[[4v6x]], [[6vlz]], [[6z6m]], [[6z6n]], [[7a5k]], [[7w59]], [[7w5a]] – hEF in 80S ribosome – Cryo EM<BR />

**[[6vmi]] – hEF in 80S mitoribosome – Cryo EM<BR />

**[[7otc]] – EcEF in 70S ribosome + antibiotics – Cryo-EM<BR />

**[[8p2f]], [[8p2g]], [[8p2h]] – SaEF in 70S ribosome – Cryo-EM<BR />

*EF-GreA/GreB

**[[2pn0]] – EF – ''Nitrosomonas europaea''<BR />

**[[2p4v]] – EcEF-GreB<br />

**[[1grj]] – EcEF-GreA<br />

**[[6ri7]], [[6rin]] – EcEF-GreB + transcriptase + DNA + RNA – Cryo EM<br />

*EF-NusA

**[[1wcl]], [[1wcn]] – EcEF C terminal – NMR<BR />

**[[2kwp]] - EcEF N terminal – NMR<BR />

**[[9f9u]] - EF – ''Saccharolobus solfataricus''<BR />

**[[9fjl]] – NusA2 – ''Sulfolobus acidocaldarius''<BR />

*EF-P

**[[1ueb]] – TtEF<BR />

**[[4v6a]] – TtEF in 70S ribosome<BR />

**[[6s8z]] – EF – ''Corynebacterium glutamicum'' <br />

**[[5wxk]] – EF + EARP – ''Neisseria meningitidis''<br />

*EF-P-like

**[[8s8u]] – EcEFL

*EF-Ts

**[[2uz8]] – hEF (mutant)<br />

**[[1b64]] – hEF guanine exchange factor domain – NMR<BR />

**[[2yy3]] – PhEF <BR />

**[[1tfe]] – TtEF<BR />

*EF-1  

**[[8b6z]], [[9p7k]] – hEF alpha in 80S ribosome – Cryo EM <br />

**[[5dqs]] – hEF β+γ <br />

**[[1nhy]] – yEF γ N terminal<br />

**[[7csl]] – PhEF α+β <br />

*EF-1 homolog

**[[8b3d]], [[8b3f]], [[9bz0]], [[9er2]], [[9fd2]] - hEFH  in RNA pol II + TCR + RNA + DNA – Cryo EM<BR />

**[[8tvy]] - yEFH  in RNA pol II + TCR + RNA + DNA – Cryo EM<BR />

**[[5xog]] - EFH  in RNA pol II + Spt4/5 + RNA + DNA – ''Komagataella pastoris'' – Cryo EM<BR />

*EF-2

**[[4v4b]] - hEF  in 40S ribosome – Cryo EM<BR />

**[[8xsx]] - hEF  in 80S ribosome + tRNA + SERBP1 + drug – Cryo EM<BR />

**[[6u43]], [[6u44]] – MnEF (mutant)  + GMPPCP <BR />

**[[6q2d]] - EF + DPH2 – ''Methanobrevibacter smithii''<BR />

*EF-3

**[[2ix3]] – yEF<BR />

**[[2iwh]] – yEF + ADPNP<BR />

**[[2iw3]] – yEF + ADP<BR />

**[[2ix8]], [[7b7d]] – yEF in 80S ribosome – Cryo EM<BR />

*EF-4 (lepA)

**[[2ywh]], [[2ywe]], [[2ywf]], [[2ywg]] - AalepA  + nucleotide - ''Aquifex aeolicus''<BR />

**[[3cb4]] - EclepA  <BR />

**[[5j8b]] - TtlepA  in 70S ribosome + GDPCP <BR />

**[[4w2e]] - TtlepA  in 70S ribosome <BR />

*EF-SelB

**[[5izk]], [[5izl]], [[5izm]] – hEF + GDP derivative<BR />

**[[1lva]] – MtEF C terminal – ''Moorella thermoacetica''<BR />

**[[4ac9]] – MmEF + GDP<BR />

**[[2pjp]] – EcEF + RNA<br />

*EF-Spt4 + EF-Spt5

**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />

**[[8p4d]], [[8p4f]], [[8w8f]] – hEF-Spt4 + EF-Spt5 in transcription complex – Cryo EM<br />

**[[5xon]], [[5xog]], [[6ir9]], [[6j4w]], [[6j4x]], [[6j4y]], [[6j4z]], [[6j50]], [[6j51]], [[8he5]], [[8jh2]] – EF-Spt4 + EF-Spt5 + EF-11 homolog in RNA polymerase II elongation complex - ''Komagataella phaffii'' - Cryo EM<br />

**[[9bct]], [[9bcu]] – EF-Spt4 + EF-Spt5 + EF-FTTA in RNA polymerase II elongation complex – ''Thermococcus kodakarensis'' - CryoEM<br />

*EF-Spt5

**[[8p4c]], [[8p4e]], [[8uis]] – hEF-Spt5 in transcription complex – Cryo EM<br />

**[[2e6z]] – hEF KOW2 motif residues 420-471 – NMR<BR />

**[[8k5p]] – yEF in POL II complex + Rai1 – Cryo EM<br />

**[[8qsz]] – EF in POL II complex – fission yeast - Cryo EM<br />

**[[2exu]] – yEF<BR />

*EF-Spt6

**[[4z2n]] – hEF middle domain residues 644-930<br />

**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />

**[[6qtc]] – CgEF SH2 domain + Tyr phosphorylated CTD – NMR <br />

**[[2xp1]] – EF SH2 domain – ''Antonospora locustae'' <br />

*EF-Spt16

**[[5umu]], [[5umt]], [[5xm2]] – hEF<br />

**[[5e5b]] - hEF  N-terminal<BR />

**[[8i17]] - hEF  + histone 2A + histone 2B<BR />

*EF-M2-1

**[[5nkx]], [[5noh]] – EF core domain – human respiratory cyncytial virus<br />

*EF-TEFM mitochondrial

**[[5ol9]] - hEF N-terminal<br />

**[[5ol8]] - hEF C-terminal<br />

**[[5ola]] - hEF + RNA polymerase + RNA + DNA<br />

**[[8u8u]], [[8u8v]], [[9bdc]], [[9bdd]] - hEF + RNA polymerase + RNA + DNA – Cryo EM<br />

*EF-CA150

**[[2dod]], [[2doe]], [[2dof]], [[2e71]], [[2kiq]], [[2kis]] – hEF FF domain – NMR<BR />

**[[3hfh]] – hEF FF domain<BR />

**[[2ysi]]– mEF WW domain - NMR<BR />

*Elongin A

**[[4hfx]] – hEloA F-box domain<br />

**[[6zuz]] – hEloA N-terminal<br />

*Elongin C

**[[5zb2]] – yEloC + Rad7<br />

**[[1hv2]] - yEloC + von-Hippel Lindau disease tumor suppressor - NMR <br />

*Elongin BC complex

**[[1vcb]], [[8bdi]], [[8bdj]] – hEloBC + VHL<br />

**[[8ei3]] – hEloBC + VHL + peptide<br />

**[[9d8p]] – hEloBC + kelch domain-containing protein + ubiquitin – Cryo EM<br />

**[[2fnj]] - mEloBC + GUSTAVUS

*Elongin ABC complex

**[[8oew]] – hEloABC + RNA Pol II + RNA + DNA – Cryo EM<br />

*Negative EF

**[[1x5p]], [[2bz2]], [[2jx2]] – hNELF-E RRM domain - NMR<br />

**[[5l3x]] – hNELF-A + hNELF-C/D <br />