22ak: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~22ak~~ is ~~ON HOLD until Paper Publication~~

==GDP human alpha1A/beta3 microtubule==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[22ak]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=22AK OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=22AK FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.41Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=22ak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=22ak OCA], [https://pdbe.org/22ak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=22ak RCSB], [https://www.ebi.ac.uk/pdbsum/22ak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=22ak ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN] Congenital fibrosis of extraocular muscles;Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.<ref>PMID:20074521</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Khoo CJ]]

[[Category: Luo JY]]

[[Category: Ti SC]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 22ak is ON HOLD  until Paper Publication
+==GDP human alpha1A/beta3 microtubule==
+<StructureSection load='22ak' size='340' side='right'caption='[[22ak]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[22ak]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=22AK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=22AK FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=22ak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=22ak OCA], [https://pdbe.org/22ak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=22ak RCSB], [https://www.ebi.ac.uk/pdbsum/22ak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=22ak ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN] Congenital fibrosis of extraocular muscles;Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.<ref>PMID:20074521</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Khoo CJ]]
+[[Category: Luo JY]]
+[[Category: Ti SC]]