9w2y: Difference between revisions

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'''Unreleased structure'''


The entry 9w2y is ON HOLD  until Paper Publication
==Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2==
<StructureSection load='9w2y' size='340' side='right'caption='[[9w2y]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9w2y]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W2Y FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w2y OCA], [https://pdbe.org/9w2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w2y RCSB], [https://www.ebi.ac.uk/pdbsum/9w2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w2y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/QCR1_BOVIN QCR1_BOVIN] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Understanding the functional mechanisms of membrane protein complexes requires structural analysis within their native membrane environment. Here, we applied cryo-electron microscopy to determine the structures of F(o)F(1) ATP synthase and respiratory supercomplexes (SCs) on sub-mitochondrial particles (SMPs) isolated from bovine heart mitochondria. Most F(o)F(1) complexes were observed as dimers stabilized by the regulatory factor IF(1), and a tetrameric assembly comprising two F(o)F(1)-IF(1) dimers arranged linearly was also identified. This finding indicates that the tetrameric units of F(o)F(1) are present in the mitochondrial inner membrane and contribute to shaping cristae tips in mammalian mitochondria. F(o) domain maps resolve the e-subunit- c(8)-ring interface and show no discrete density for a tightly bound lipid within the c(8)-ring. In addition to the previously reported SCs compositions CI(1)CIII(2)CIV(1) and CI(1)CIII(2)CIV(2), our analysis identified an additional assembly with the composition CI(1)CIII(2)CIV(3), as well as a CI(2)CIII(2)CIV(6) mega-complex. This approach enables rapid structural determination of F(o)F(1) ATP synthase and SCs from minimal membrane fractions, providing a foundation for elucidating the molecular basis of metabolic disorders and mitochondrial diseases at the level of higher-order architecture.


Authors: Nakano, A., Masuya, T., Akisada, S., Ishikawa-Fukuda, M., Mitsuoka, K., Miyoshi, H., Murai, M., Yokoyama, K.
Structures of respiratory supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane.,Nakano A, Masuya T, Akisada S, Ishikawa-Fukuda M, Mitsuoka K, Miyoshi H, Murai M, Yokoyama K Nat Commun. 2026 Mar 17. doi: 10.1038/s41467-026-70578-x. PMID:41844608<ref>PMID:41844608</ref>


Description: Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Miyoshi, H]]
<div class="pdbe-citations 9w2y" style="background-color:#fffaf0;"></div>
[[Category: Ishikawa-Fukuda, M]]
== References ==
[[Category: Murai, M]]
<references/>
[[Category: Mitsuoka, K]]
__TOC__
[[Category: Yokoyama, K]]
</StructureSection>
[[Category: Akisada, S]]
[[Category: Bos taurus]]
[[Category: Nakano, A]]
[[Category: Large Structures]]
[[Category: Masuya, T]]
[[Category: Akisada S]]
[[Category: Ishikawa-Fukuda M]]
[[Category: Masuya T]]
[[Category: Mitsuoka K]]
[[Category: Miyoshi H]]
[[Category: Murai M]]
[[Category: Nakano A]]
[[Category: Yokoyama K]]
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