23xo: Difference between revisions

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'''Unreleased structure'''


The entry 23xo is ON HOLD
==Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Rimeporide in an outward-open conformation==
 
<StructureSection load='23xo' size='340' side='right'caption='[[23xo]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
Authors: Cong, Y., Kong, F., Zhu, A., Yan, C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[23xo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=23XO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=23XO FirstGlance]. <br>
Description: Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Rimeporide in an outward-open conformation
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.16&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1E6E:~{N}-carbamimidoyl-2-methyl-4,5-bis(methylsulfonyl)benzamide'>A1E6E</scene></td></tr>
[[Category: Kong, F]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=23xo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=23xo OCA], [https://pdbe.org/23xo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=23xo RCSB], [https://www.ebi.ac.uk/pdbsum/23xo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=23xo ProSAT]</span></td></tr>
[[Category: Zhu, A]]
</table>
[[Category: Yan, C]]
== Function ==
[[Category: Cong, Y]]
[https://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cong Y]]
[[Category: Kong F]]
[[Category: Yan C]]
[[Category: Zhu A]]
Retrieved from "https://proteopedia.org/23xo"