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'''Unreleased structure'''


The entry 29mo is ON HOLD  until sometime in the future
==Crystal structure of human CLK3 in complex with AZ176==
 
<StructureSection load='29mo' size='340' side='right'caption='[[29mo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Zerva, A., Raig, N., Hanke, T., Knapp, S., Kraemer, A., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[29mo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=29MO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=29MO FirstGlance]. <br>
Description: Crystal structure of human CLK3 in complex with AZ176
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
[[Category: Zerva, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=29mo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=29mo OCA], [https://pdbe.org/29mo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=29mo RCSB], [https://www.ebi.ac.uk/pdbsum/29mo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=29mo ProSAT]</span></td></tr>
[[Category: Hanke, T]]
</table>
[[Category: Structural Genomics Consortium (Sgc)]]
== Function ==
[[Category: Kraemer, A]]
[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref>
[[Category: Raig, N]]
== References ==
[[Category: Knapp, S]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hanke T]]
[[Category: Knapp S]]
[[Category: Kraemer A]]
[[Category: Raig N]]
[[Category: Zerva A]]
Retrieved from "https://proteopedia.org/29mo"