9dn9: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==RamR variant S2.4 complexed with 1S-1-phenyl-1,2,3,4-tetrahydroisoquinoline== | |||
<StructureSection load='9dn9' size='340' side='right'caption='[[9dn9]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9dn9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DN9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BED:(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline'>A1BED</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dn9 OCA], [https://pdbe.org/9dn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dn9 RCSB], [https://www.ebi.ac.uk/pdbsum/9dn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dn9 ProSAT]</span></td></tr> | ||
[[Category: Kim | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HTHTR_SALTY HTHTR_SALTY] Transcriptional regulator (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Represses the transcription of the transcriptional activator RamA and, thereby, leads to repression of the expression of the efflux pump subunits AcrA and AcrB, and TolC (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Acts by binding directly to the promoter region of the ramA gene (PubMed:22123696, PubMed:22948865, PubMed:23800819). Promoter binding may be inhibited partially by the small regulatory RNA StyR3, perhaps thereby ensuring a basal level of expression of RamA.[UniProtKB:A0A0H3GJQ8]<ref>PMID:18443112</ref> <ref>PMID:22123696</ref> <ref>PMID:22948865</ref> <ref>PMID:23800819</ref> <ref>PMID:30655545</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | |||
[[Category: Kim W]] | |||
[[Category: Zhang YJ]] | |||
Latest revision as of 06:15, 8 April 2026
RamR variant S2.4 complexed with 1S-1-phenyl-1,2,3,4-tetrahydroisoquinoline
| ||||||||||||
