9ubd: Difference between revisions
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The | ==The Structural Basis of the Recognition of the Histone Variant H2A.Z by the SRCAP Catalytic Subunit== | ||
<StructureSection load='9ubd' size='340' side='right'caption='[[9ubd]], [[Resolution|resolution]] 2.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ubd]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UBD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ubd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ubd OCA], [https://pdbe.org/9ubd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ubd RCSB], [https://www.ebi.ac.uk/pdbsum/9ubd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ubd ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hong JJ]] | |||
[[Category: Jiang JS]] | |||
[[Category: Tan WS]] | |||
Latest revision as of 06:31, 8 April 2026
The Structural Basis of the Recognition of the Histone Variant H2A.Z by the SRCAP Catalytic Subunit
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