9ut3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 9ut3 is ~~ON HOLD until Paper Publication~~

==The helicase module of the helicase-primase complex from HHV1 bound with ssDNA and amenamevir==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9ut3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UT3 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9UT3 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.88Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BXD:N-(2,6-dimethylphenyl)-N-{2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl}-1,1-dioxo-1lambda~6~-thiane-4-carboxamide'>A1BXD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ut3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ut3 OCA], [https://pdbe.org/9ut3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ut3 RCSB], [https://www.ebi.ac.uk/pdbsum/9ut3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ut3 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/HELI_HHV11 HELI_HHV11] Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.[HAMAP-Rule:MF_04030]

__TOC__

</StructureSection>

[[Category: Human alphaherpesvirus 1]]

[[Category: Large Structures]]

[[Category: Saccharomyces cerevisiae S288C]]

[[Category: Synthetic construct]]

[[Category: Hamada K]]

[[Category: Kise Y]]

[[Category: Nureki O]]

[[Category: Sato K]]

[[Category: Sengoku T]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ut3 is ON HOLD  until Paper Publication
+==The helicase module of the helicase-primase complex from HHV1 bound with ssDNA and amenamevir==
+<StructureSection load='9ut3' size='340' side='right'caption='[[9ut3]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ut3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UT3 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BXD:N-(2,6-dimethylphenyl)-N-{2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl}-1,1-dioxo-1lambda~6~-thiane-4-carboxamide'>A1BXD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ut3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ut3 OCA], [https://pdbe.org/9ut3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ut3 RCSB], [https://www.ebi.ac.uk/pdbsum/9ut3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ut3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HELI_HHV11 HELI_HHV11] Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.[HAMAP-Rule:MF_04030]
+__TOC__
+</StructureSection>
+[[Category: Human alphaherpesvirus 1]]
+[[Category: Large Structures]]
+[[Category: Saccharomyces cerevisiae S288C]]
+[[Category: Synthetic construct]]
+[[Category: Hamada K]]
+[[Category: Kise Y]]
+[[Category: Nureki O]]
+[[Category: Sato K]]
+[[Category: Sengoku T]]