9ut5: Difference between revisions
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The | ==The helicase-primase complex from HHV1 bound with ssDNA and pritelivir== | ||
<StructureSection load='9ut5' size='340' side='right'caption='[[9ut5]], [[Resolution|resolution]] 3.32Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ut5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UT5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.32Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BXB:~{N}-methyl-~{N}-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)ethanamide'>A1BXB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ut5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ut5 OCA], [https://pdbe.org/9ut5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ut5 RCSB], [https://www.ebi.ac.uk/pdbsum/9ut5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ut5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HELI_HHV11 HELI_HHV11] Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.[HAMAP-Rule:MF_04030] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human alphaherpesvirus 1]] | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Hamada K]] | |||
[[Category: Kise Y]] | |||
[[Category: Nureki O]] | |||
[[Category: Sato K]] | |||
[[Category: Sengoku T]] | |||
Latest revision as of 06:31, 8 April 2026
The helicase-primase complex from HHV1 bound with ssDNA and pritelivir
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