9ysq: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
m Protected "9ysq" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 9ysq is ON HOLD
==Structure of a human NUAK1-MARK3 kinase domain chimera in complex with inhibitor==
 
<StructureSection load='9ysq' size='340' side='right'caption='[[9ysq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ysq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YSQ FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CZY:3-[[2-[[2-[bis(fluoranyl)methoxy]-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-chloranyl-pyrimidin-4-yl]amino]thiophene-2-carboxamide'>A1CZY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ysq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ysq OCA], [https://pdbe.org/9ysq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ysq RCSB], [https://www.ebi.ac.uk/pdbsum/9ysq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ysq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MARK3_HUMAN MARK3_HUMAN] Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.<ref>PMID:16980613</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chini FD]]
[[Category: Mao DYL]]
[[Category: Sicheri F]]
Retrieved from "https://proteopedia.org/9ysq"