9nza: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The~~ entry ~~9nza~~ is ~~ON HOLD until Paper Publication~~

==Crystal structure of human OGG1 (WT) in a product bound state in the presence of the agonist F01==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9nza]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NZA OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9NZA FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C6T:(2R,3E)-2-hydroxy-5-oxopent-3-en-1-yl+dihydrogen+phosphate'>A1C6T</scene>, <scene name='pdbligand=OXG:8-OXOGUANINE'>OXG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9nza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nza OCA], [https://pdbe.org/9nza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nza RCSB], [https://www.ebi.ac.uk/pdbsum/9nza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nza ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.

== Function ==

[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Synthetic construct]]

[[Category: Arvai AS]]

[[Category: Syed A]]

[[Category: Tainer JA]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9nza is ON HOLD  until Paper Publication
+==Crystal structure of human OGG1 (WT) in a product bound state in the presence of the agonist F01==
+<StructureSection load='9nza' size='340' side='right'caption='[[9nza]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9nza]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NZA FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C6T:(2R,3E)-2-hydroxy-5-oxopent-3-en-1-yl+dihydrogen+phosphate'>A1C6T</scene>, <scene name='pdbligand=OXG:8-OXOGUANINE'>OXG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nza OCA], [https://pdbe.org/9nza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nza RCSB], [https://www.ebi.ac.uk/pdbsum/9nza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nza ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
+== Function ==
+[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Arvai AS]]
+[[Category: Syed A]]
+[[Category: Tainer JA]]