9hmi: Difference between revisions
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==Crystal structure of the Calf domains of Integrin Alpha5 in complex with angiopoietin2 peptide== | |||
<StructureSection load='9hmi' size='340' side='right'caption='[[9hmi]], [[Resolution|resolution]] 2.78Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hmi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HMI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hmi OCA], [https://pdbe.org/9hmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hmi RCSB], [https://www.ebi.ac.uk/pdbsum/9hmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hmi ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ITA5_HUMAN ITA5_HUMAN] Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Leppanen VML]] | |||
[[Category: Murthy AV]] | |||
[[Category: Ponna SK]] | |||
[[Category: Saharinen PI]] | |||
[[Category: Sipila TJO]] | |||
Latest revision as of 11:36, 24 May 2026
Crystal structure of the Calf domains of Integrin Alpha5 in complex with angiopoietin2 peptide
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