9obu: Difference between revisions
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==glycine/glutamate and Mg2+-bound GluN1a/2B NMDAR== | |||
<StructureSection load='9obu' size='340' side='right'caption='[[9obu]], [[Resolution|resolution]] 3.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9obu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OBU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.16Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9obu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9obu OCA], [https://pdbe.org/9obu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9obu RCSB], [https://www.ebi.ac.uk/pdbsum/9obu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9obu ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Furukawa H]] | |||
[[Category: Steigerwald R]] | |||
Latest revision as of 12:00, 24 May 2026
glycine/glutamate and Mg2+-bound GluN1a/2B NMDAR
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