29os: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 29os is ~~ON HOLD~~

==AD fold in mouse injected with seeds of AD==

~~Authors~~: ~~Lovestam~~, S.L., ~~Scheres~~, S.H.W., ~~Goedert~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[29os]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=29OS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=29OS FirstGlance]. <br>

~~Description~~: ~~AD fold~~ in ~~mouse injected~~ with ~~seeds~~ of AD

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=29os FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=29os OCA], [https://pdbe.org/29os PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=29os RCSB], [https://www.ebi.ac.uk/pdbsum/29os PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=29os ProSAT]</span></td></tr>

[[Category: ~~Scheres, S.H.W~~]]

</table>

[[Category: Lovestam~~, S.L~~]]

== Disease ==

[[Category: ~~Goedert, M~~]]

[https://www.uniprot.org/uniprot/TAU_MOUSE TAU_MOUSE] May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4-dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease.

== Function ==

[https://www.uniprot.org/uniprot/TAU_MOUSE TAU_MOUSE] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Goedert M]]

[[Category: Lovestam SL]]

[[Category: Scheres SHW]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 29os is ON HOLD
+==AD fold in mouse injected with seeds of AD==
+<StructureSection load='29os' size='340' side='right'caption='[[29os]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
-Authors: Lovestam, S.L., Scheres, S.H.W., Goedert, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[29os]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=29OS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=29OS FirstGlance]. <br>
-Description: AD fold in mouse injected with seeds of AD
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=29os FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=29os OCA], [https://pdbe.org/29os PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=29os RCSB], [https://www.ebi.ac.uk/pdbsum/29os PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=29os ProSAT]</span></td></tr>
-[[Category: Scheres, S.H.W]]
+</table>
-[[Category: Lovestam, S.L]]
+== Disease ==
-[[Category: Goedert, M]]
+[https://www.uniprot.org/uniprot/TAU_MOUSE TAU_MOUSE] May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4-dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease.
+== Function ==
+[https://www.uniprot.org/uniprot/TAU_MOUSE TAU_MOUSE] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Goedert M]]
+[[Category: Lovestam SL]]
+[[Category: Scheres SHW]]