9v95: Difference between revisions

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'''Unreleased structure'''


The entry 9v95 is ON HOLD  until Paper Publication
==Cryo-EM structure of the ArlB filament of Haloarcula marismortui==
<StructureSection load='9v95' size='340' side='right'caption='[[9v95]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9v95]] is a 33 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V95 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.18&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v95 OCA], [https://pdbe.org/9v95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v95 RCSB], [https://www.ebi.ac.uk/pdbsum/9v95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v95 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5V0B8_HALMA Q5V0B8_HALMA] Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.[RuleBase:RU361282]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Many archaea swim by means of rotating helical filaments called archaella. Most archaella are about 10 nm in diameter and comprise multiple copies of the protein archaellin. Here, we describe two archaellum structures formed by the ArlA2 or ArlB archaellins from the haloarchaeon Haloarcula marismortui. We found that both filaments have an additional proteinaceous outer sheath surrounding their inner core, a feature not observed previously in archaea. The outer sheath structures of the two filaments differ fundamentally. The outer domain of ArlB archaellin rotates by 180( degrees ), forming stable dimers that likely increase the filament rigidity. In contrast, neither rotation nor dimerization of the outer domain was observed in ArlA2 filaments. 3D variability analysis demonstrated that the motions of ArlA2 and ArlB filaments are significantly distinct. Additionally, the ArlB filament displays a larger negatively charged surface area than ArlA2, which may help adaptation to higher salt concentrations. Our structural findings provide insight into how the two filaments can adapt to their different environments. Larger archaellins with additional outer domains can be found in various groups of archaea. We propose that such proteins may allow hosts to modify the properties of their archaella to enhance environmental adaptation.


Authors: Meshcheryakov, V.A., Hyun, J., Syutkin, A.S., Pyatibratov, M.G., Wolf, M.
Two types of sheathed archaellum structures from Haloarcula marismortui differ in their outer layer architectures.,Meshcheryakov VA, Hyun J, Shibata S, Syutkin AS, Pyatibratov MG, Wolf M Nat Commun. 2026 May 6. doi: 10.1038/s41467-026-72670-8. PMID:42091601<ref>PMID:42091601</ref>


Description: Cryo-EM structure of the ArlB filament of Haloarcula marismortui
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Pyatibratov, M.G]]
<div class="pdbe-citations 9v95" style="background-color:#fffaf0;"></div>
[[Category: Wolf, M]]
== References ==
[[Category: Meshcheryakov, V.A]]
<references/>
[[Category: Syutkin, A.S]]
__TOC__
[[Category: Hyun, J]]
</StructureSection>
[[Category: Haloarcula marismortui]]
[[Category: Large Structures]]
[[Category: Hyun J]]
[[Category: Meshcheryakov VA]]
[[Category: Pyatibratov MG]]
[[Category: Syutkin AS]]
[[Category: Wolf M]]
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