9vul: Difference between revisions
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==Cryo-EM structure of the human measles virus RNA-dependent RNA polymerase bound to allosteric inhibitor ERDRP-0519== | |||
<StructureSection load='9vul' size='340' side='right'caption='[[9vul]], [[Resolution|resolution]] 3.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9vul]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Measles_virus_genotype_A-vaccine Measles virus genotype A-vaccine] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VUL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EF9:2-methyl-~{N}-[4-[(2~{S})-2-(2-morpholin-4-ylethyl)piperidin-1-yl]sulfonylphenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide'>A1EF9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vul OCA], [https://pdbe.org/9vul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vul RCSB], [https://www.ebi.ac.uk/pdbsum/9vul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vul ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Du | == Function == | ||
[[Category: Ru | [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/PHOSP_MEASA PHOSP_MEASA] Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Measles virus genotype A-vaccine]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Du T]] | |||
[[Category: Ru H]] | |||
[[Category: Wang J]] | |||
[[Category: Wu S]] | |||
Latest revision as of 05:08, 27 May 2026
Cryo-EM structure of the human measles virus RNA-dependent RNA polymerase bound to allosteric inhibitor ERDRP-0519
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