9vzs: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9vzs is ~~ON HOLD until Paper Publication~~

==X-ray structure of human PPARalpha ligand binding domain-10-hydroxystearic acid (10-HSA) co-crystals obtained by cross-seeding==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9vzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VZS OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9VZS FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.455Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WAD:(10R)-10-hydroxyoctadecanoic+acid'>WAD</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9vzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vzs OCA], [https://pdbe.org/9vzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vzs RCSB], [https://www.ebi.ac.uk/pdbsum/9vzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vzs ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Honda A]]

[[Category: Ishii I]]

[[Category: Kamata S]]

[[Category: Krause HM]]

[[Category: Liu J]]

[[Category: Watase K]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9vzs is ON HOLD  until Paper Publication
+==X-ray structure of human PPARalpha ligand binding domain-10-hydroxystearic acid (10-HSA) co-crystals obtained by cross-seeding==
+<StructureSection load='9vzs' size='340' side='right'caption='[[9vzs]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9vzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VZS FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.455&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WAD:(10R)-10-hydroxyoctadecanoic+acid'>WAD</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vzs OCA], [https://pdbe.org/9vzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vzs RCSB], [https://www.ebi.ac.uk/pdbsum/9vzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vzs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Honda A]]
+[[Category: Ishii I]]
+[[Category: Kamata S]]
+[[Category: Krause HM]]
+[[Category: Liu J]]
+[[Category: Watase K]]