9x65: Difference between revisions

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'''Unreleased structure'''


The entry 9x65 is ON HOLD  until 2027-04-14
==Cryo-EM structure of the human KCNQ2/3 heteromer channel in the XEN1101-bound open state==
 
<StructureSection load='9x65' size='340' side='right'caption='[[9x65]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
Authors: Cheng, X.Y., Wan, S.Y., Hou, P.P., Zhang, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9x65]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9X65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9X65 FirstGlance]. <br>
Description: Cryo-EM structure of the human KCNQ2/3 heteromer channel in the XEN1101-bound open state
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.19&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EY8:~{N}-[4-(6-fluoranyl-3,4-dihydro-1~{H}-isoquinolin-2-yl)-2,6-dimethyl-phenyl]-3,3-dimethyl-butanamide'>A1EY8</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr>
[[Category: Cheng, X.Y]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9x65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9x65 OCA], [https://pdbe.org/9x65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9x65 RCSB], [https://www.ebi.ac.uk/pdbsum/9x65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9x65 ProSAT]</span></td></tr>
[[Category: Zhang, J]]
</table>
[[Category: Hou, P.P]]
== Disease ==
[[Category: Wan, S.Y]]
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.  The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
== Function ==
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng XY]]
[[Category: Hou PP]]
[[Category: Wan SY]]
[[Category: Zhang J]]
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