9zmf: Difference between revisions

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'''Unreleased structure'''


The entry 9zmf is ON HOLD  until Paper Publication
==Structure of PTP1b complexed with difluoromethylphosphonate inhibitor Compound 10==
 
<StructureSection load='9zmf' size='340' side='right'caption='[[9zmf]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
Authors: Palte, R.L., Schneider, S.E., Candito, D.A., Zheng, X.M., Huang, H., Stinn, A., Lindner, I.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9zmf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZMF FirstGlance]. <br>
Description: Structure of PTP1b complexed with difluoromethylphosphonate inhibitor Compound 10
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C3B:[(3-bromo-5-carbamoyl-1-benzothiophen-2-yl)di(fluoro)methyl]phosphonic+acid'>A1C3B</scene></td></tr>
[[Category: Huang, H]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zmf OCA], [https://pdbe.org/9zmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zmf RCSB], [https://www.ebi.ac.uk/pdbsum/9zmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zmf ProSAT]</span></td></tr>
[[Category: Schneider, S.E]]
</table>
[[Category: Stinn, A]]
== Function ==
[[Category: Palte, R.L]]
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
[[Category: Candito, D.A]]
== References ==
[[Category: Zheng, X.M]]
<references/>
[[Category: Lindner, I]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Candito DA]]
[[Category: Huang H]]
[[Category: Lindner I]]
[[Category: Palte RL]]
[[Category: Schneider SE]]
[[Category: Stinn A]]
[[Category: Zheng XM]]
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