9zmg: Difference between revisions
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==Structure of PTP1b complexed with difluoromethylphosphonate inhibitor Compound 15== | |||
<StructureSection load='9zmg' size='340' side='right'caption='[[9zmg]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9zmg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZMG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C3C:[(3-bromo-5-{[(pyridazin-3-yl)methyl]carbamoyl}-1-benzothiophen-2-yl)di(fluoro)methyl]phosphonic+acid'>A1C3C</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zmg OCA], [https://pdbe.org/9zmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zmg RCSB], [https://www.ebi.ac.uk/pdbsum/9zmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zmg ProSAT]</span></td></tr> | ||
[[Category: Huang | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: Zheng | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Candito DA]] | |||
[[Category: Huang H]] | |||
[[Category: Lindner I]] | |||
[[Category: Palte RL]] | |||
[[Category: Schneider SE]] | |||
[[Category: Stinn A]] | |||
[[Category: Zheng XM]] | |||
Latest revision as of 05:17, 27 May 2026
Structure of PTP1b complexed with difluoromethylphosphonate inhibitor Compound 15
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