Polyamine oxidase: Difference between revisions
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'''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide. PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death. PAO is involved in polyamine catabolism and uses FAD as a cofactor<ref>PMID:8584670</ref>. | '''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide. PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death. PAO is involved in polyamine catabolism and uses FAD as a cofactor<ref>PMID:8584670</ref>.<br /> | ||
'''Spermine oxidase''' (PAO-1) oxydizes spermine<ref>PMID:21809080</ref>.<br /> | |||
*<scene name='48/486448/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres. | *<scene name='48/486448/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres. | ||
*<scene name='48/486448/Cv/5'>Spermidine binding site</scene>. | *<scene name='48/486448/Cv/5'>Spermidine binding site</scene>. | ||
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*Spermine oxidase or PAO-1 | *Spermine oxidase or PAO-1 | ||
**[[7oxl]] – hPAO-1 – human<br /> | **[[7oxl]] – hPAO-1 + FAD derivative – human<br /> | ||
**[[7oy0]] – hPAO-1 + inhibitor<br /> | **[[7oy0]] – hPAO-1 + FAD derivative + inhibitor<br /> | ||
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Latest revision as of 10:30, 31 May 2026
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3D structures of polyamine oxidase
Updated on 31-May-2026
