9ozk: Difference between revisions

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'''Unreleased structure'''


The entry 9ozk is ON HOLD  until Paper Publication
==Structure of human Sec23a/Sec24a/Sec22b bound to ligand CPD2==
 
<StructureSection load='9ozk' size='340' side='right'caption='[[9ozk]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors: Goldberg, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ozk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OZK FirstGlance]. <br>
Description: Structure of human Sec23a/Sec24a/Sec22b bound to ligand CPD2
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CE9:(2~{R})-2-phenylcyclobutane-1,1-dicarboxylic+acid'>A1CE9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Goldberg, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ozk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ozk OCA], [https://pdbe.org/9ozk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ozk RCSB], [https://www.ebi.ac.uk/pdbsum/9ozk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ozk ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[https://omim.org/entry/607812 607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>
== Function ==
[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Goldberg J]]
Retrieved from "https://proteopedia.org/9ozk"