9p09: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9p09 is ~~ON HOLD until Paper Publication~~

==Structure of human Sec23a/Sec24a/Sec22b bound to ligand CPD14==

~~Authors~~: ~~Goldberg~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[9p09]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P09 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9P09 FirstGlance].

~~Description~~: ~~Structure~~ of ~~human Sec23a~~/~~Sec24a~~/~~Sec22b bound~~ to ~~ligand CPD14~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CF9:(2~{R},3~{R})-2-[(3-methoxyphenyl)methyl]-3-phenyl-cyclopropane-1,1-dicarboxylic+acid'>A1CF9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: Goldberg, J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9p09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p09 OCA], [https://pdbe.org/9p09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p09 RCSB], [https://www.ebi.ac.uk/pdbsum/9p09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p09 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[https://omim.org/entry/607812 607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>

== Function ==

[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Goldberg J]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9p09 is ON HOLD  until Paper Publication
+==Structure of human Sec23a/Sec24a/Sec22b bound to ligand CPD14==
+<StructureSection load='9p09' size='340' side='right'caption='[[9p09]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
-Authors: Goldberg, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9p09]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9P09 FirstGlance]. <br>
-Description: Structure of human Sec23a/Sec24a/Sec22b bound to ligand CPD14
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CF9:(2~{R},3~{R})-2-[(3-methoxyphenyl)methyl]-3-phenyl-cyclopropane-1,1-dicarboxylic+acid'>A1CF9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Goldberg, J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9p09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p09 OCA], [https://pdbe.org/9p09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p09 RCSB], [https://www.ebi.ac.uk/pdbsum/9p09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p09 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[https://omim.org/entry/607812 607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Goldberg J]]