9sna: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9sna is ~~ON HOLD until Paper Publication~~

==BRCA1-A complex bound to K63-diUbATA - open form StateC StateP==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9sna]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SNA OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9SNA FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JPL:(3~{R})-4-azanyl-3-sulfanyl-butanoic+acid'>A1JPL</scene>, <scene name='pdbligand=DAB:2,4-DIAMINOBUTYRIC+ACID'>DAB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9sna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sna OCA], [https://pdbe.org/9sna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sna RCSB], [https://www.ebi.ac.uk/pdbsum/9sna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sna ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/ABRX1_HUMAN ABRX1_HUMAN] Disease susceptibility is associated with variants affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/ABRX1_HUMAN ABRX1_HUMAN] Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.<ref>PMID:17525340</ref> <ref>PMID:17643121</ref> <ref>PMID:17643122</ref> <ref>PMID:18077395</ref> <ref>PMID:19261748</ref> <ref>PMID:22357538</ref> <ref>PMID:26778126</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Murachelli AG]]

[[Category: Sixma TK]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9sna is ON HOLD  until Paper Publication
+==BRCA1-A complex bound to K63-diUbATA - open form StateC StateP==
+<StructureSection load='9sna' size='340' side='right'caption='[[9sna]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9sna]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SNA FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JPL:(3~{R})-4-azanyl-3-sulfanyl-butanoic+acid'>A1JPL</scene>, <scene name='pdbligand=DAB:2,4-DIAMINOBUTYRIC+ACID'>DAB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sna OCA], [https://pdbe.org/9sna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sna RCSB], [https://www.ebi.ac.uk/pdbsum/9sna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sna ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/ABRX1_HUMAN ABRX1_HUMAN] Disease susceptibility is associated with variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/ABRX1_HUMAN ABRX1_HUMAN] Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.<ref>PMID:17525340</ref> <ref>PMID:17643121</ref> <ref>PMID:17643122</ref> <ref>PMID:18077395</ref> <ref>PMID:19261748</ref> <ref>PMID:22357538</ref> <ref>PMID:26778126</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Murachelli AG]]
+[[Category: Sixma TK]]