9ve2: Difference between revisions
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==Crystal Structure of Human Peroxiredoxin I in Complex with Fluvastatin== | |||
<StructureSection load='9ve2' size='340' side='right'caption='[[9ve2]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ve2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VE2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=115:(3R,5S,6E)-7-[3-(4-FLUOROPHENYL)-1-(PROPAN-2-YL)-1H-INDOL-2-YL]-3,5-DIHYDROXYHEPT-6-ENOIC+ACID'>115</scene></td></tr> | ||
[[Category: Xu | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ve2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ve2 OCA], [https://pdbe.org/9ve2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ve2 RCSB], [https://www.ebi.ac.uk/pdbsum/9ve2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ve2 ProSAT]</span></td></tr> | ||
[[Category: Zhang | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PRDX1_HUMAN PRDX1_HUMAN] Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Xu H]] | |||
[[Category: Zhang H]] | |||
Latest revision as of 07:22, 17 June 2026
Crystal Structure of Human Peroxiredoxin I in Complex with Fluvastatin
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