Spike protein

spinqualitylabelsall models Human coronavirus NL63 spike glycoprotein (magenta) complex with its ligand ACE2 (green) (PDB code 3kbh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function The coronavirus spike protein (Spi, also called protein S) binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus . See also ACEII and SARS SARS-CoV-2 protein S SARS-CoV-2 spike protein mutations Engineered Protein Inhibitors for SARS-CoV-2 Entry Coronavirus Disease 2019 (COVID-19) and the animation at SARS-CoV-2 protein S priming by furin and SARS-CoV-2 spike protein fusion transformation Disease Numerous viral diseases are causing world-shattering consequences and the current pandemic of CoVID-2019 is the recent one. Relevance The spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential CoVID-2019 antiviral treatment. Structural highlights The SARS-CoV Spi receptor binding domain complex with its cellular receptor - ACE2 - shows the interactions to ACE2 "hot spot". See Also SARS-CoV-2 protein S SARS-CoV-2 protein S priming by furin where the priming step induced by furin cleavage is animated. SARS-CoV-2 spike protein fusion transformation with an animation and explanation of the membrane fusion mechanism. SARS-CoV-2 spike protein mutations Coronavirus Disease 2019 (COVID-19) Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up about 6vsb Spike Protein (Hebrew) 3D Structures of spike protein Spike protein 3D structures

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Michal Harel, Eric Martz, Alexander Berchansky, Joel L. Sussman